P1424 Long-term follow-up in patients undergoing early surgery (repair) for severe degenerative mitral regurgitation

Abstract

Abstract Discordance between studies drives debate regarding the "ideal" (early surgery vs watchful waiting) management of asymptomatic severe mitral regurgitation (MR) in valve prolapse (MVP). Independently on disagreement between studies, strategies are mainly oriented towards early surgery in centers that can achieve <1% mortality rates and >95% repair rates. Data on a detailed evaluation of outcomes in terms of left ventricular ejection fraction (LV EF) in the early repair strategy are lacking. Aims of this study in a large population undergoing early MVP repair are: a) to assess LV function comparing EF and volumes in the follow-up (FU) at 6 month (6ms) and 3 year (3ys) b) to verify whether pre-op volumes and EF may predict functional results c) to compare these findings to the surgical procedure (simple or complex) and to the residual MR. Between 2008 and 2018, 1000 cases underwent early MV repair in our Center. We retrospectively selected 300 pts with pre-op 2D and 3DTTE, 6 ms and 3ys 2DTTE FU. Results: 286 pts (200 males; 61 ± 12 ys; 222 Barlow, 78 fibroelastic deficiency at 3DTTE examination) had MV surgery (96% reparability; 14 MV replacement after a first attempt of repair). 87 had complex MVP and in 56 the surgical procedure was complex. MR at 6ms <1+ (262 pts) predicted stability of MR at 3ys, while in the 38 cases with MR >1+, MR increased at 3ys (2,6±.6+). Complexity of pre-op 3D morphology predicted complexity of MV repair and identified pts with higher risk of MR recurrence. Table summarizes functional results showing that early restoration of MR, causes significant morphological and haemodynamic improvements at 6 ms without significant additional changes at 3ys. Pre-op systolic LV volume and EF significantly correlated with LV remodelling. In conclusions a) early MV repair is associated with favourable LV remodelling and stable systolic function at FU; b) 2DTTE predicts in an early surgical strategy favourable LV remodelling c) pre-operative 3DTTE morphology (simple vs complex MVP) predicts repair procedure (simple vs complex) that in the large majority (91%) is associated with freedom from MR recurrence. Table Pre-op 6-month FU 3-years FU Left ventricular end diastolic volume (ml) 140 ± 41 104 ± 30 * 103 ± 35 Left ventricular end systolic volume (ml) 49 ± 19 45 ± 19* 43 ± 22 Left ventricular ejection fraction (%) 65 ± 7 58 ± 8* 59 ± 7§ Mitral regurgitation (+) 3.9 ± 0.2 0.6±.6* 0.9±.9§ Left atrial volume (ml) 123 ± 48 91 ± 35* 87 ± 45 *= p < 0.01 6 ms vs pre-op; §=p < 0.01 3ys vs 6 ms