P141 Mucosal cytokine profiles in early, untreated Crohn's disease

Abstract

index (BMI), serum resistin levels and IR values. Erythrocyte sedimentation rate and C-reactive protein levels were significantly higher in IBD patients (p < 0.0001). No statistically significant difference was noted between ulcerative colitis patients, Crohn’s disease patients and healthy subjects with respect to age, sex, BMI, serum resistin levels and IR values. Serum resistin levels were significantly higher in IBD patients who had received and/or were receiving steroids (n = 15) when compared to patients who did not receive steroid therapy (n = 27; p < 0.001). There was no difference between these two groups with respect to age, sex, BMI, fasting serum glucose levels and IR values. The disease activity of patients with ulcerative colitis and Crohn’s disease was evaluated according to Seo activity index and Crohn’s disease activity index, respectively. There was no significant difference between patients with mild disease activity (n = 30) and moderate disease activity (n = 12) with respect to sex, BMI and IR values. Patients with mild disease activity were significantly older (p < 0.05) and had significantly lower serum resistin levels (p < 0.05) compared to those with moderate disease activity. Conclusions: In our study, serum resistin levels which did not differ between IBD patients and healthy subjects, were elevated parallel to increasing disease activity. Higher serum resistin levels were also found in patients who received steroids owing to disease activation. IBD patients in remission did not display either increase in resistin levels or IR. Neither IBD patients in remission did not display either increase in resistin levels or IR.