P134 – 2952: Magnetic resonance imaging findings in pediatric tuberous sclerosis patients

Abstract

Objectives To assess magnetic resonance imaging (MRI) findings in a group of 20 children below the age of 18 years diagnosed with tuberous sclerosis (TS). Methods The age of imaging and period of follow up, MRI characteristics of cortical tubers, subependymal nodules and other findings were recorded. Results Male/Female ratio was 6/14. Age at first imaging was 5 months to 18 years. Nine patients had follow-up imaging after 5 months–8 years. Seven of them were stable. One patient underwent tuber resection and temporal lobectomy. One patient had a partially calcified 2×1.5 cm subependymal giant cell astrocytoma which showed cystic degeneration and growed into 3×5.5 cm size on follow up. Six of all had cranial tomography. None had spinal imaging. Cortical tubers were mostly seen in frontal and parietal lobes. 2 patients had cerebellar tubers which were calcified. Ten patients had cortical cystic degeneration, 12 had calcification and 2 had Gadolinium enhancement in cortical tubers. Radial band was present in all but one. Subependymal nodules were mostly located around corpus of lateral ventricles and adjacent to foramen Monro (13/19). Amount of subependymal nodules ranged between 3–15 with a size of 2–9 mm. Seven patients had Gadolinium enhancement and 15 had calcification in subependymal nodules. One patient did not have subependymal nodules. In this study group 12/20 patients had enlarged perivascular space. Although 9/20 had thin corpus callosum and 12/20 had enlarged ventricles, only one patient showed cerebral atrophy. Conclusion We observed that in our patients quantity of cortical tubers in parietal lobes were similar to frontal lobes. 2/20 (10%) patients showed tubers in cerebellum. 60% revealed enlarged perivascular spaces which may be interesting to study in larger groups of TS patients.