P13.18: Fetal magnetic resonance imaging (MRI) impact on prenatal management of ultrasound detected fetal central nervous system malformations

Abstract

Objectives: The objective of this study was to measure the fetal brain volume (FBV) and vascularization and blood flow using transvaginal 3DPD sonography late in the first trimester of pregnancy. Methods: 3DPD sonographic examinations with the VOCAL imaging analysis program were performed involving 36 normal fetuses from 10 to 13 weeks of gestation. FBV and 3DPD indices related to the fetal brain vascularization (vascularization index (VI), flow index (FI), and vascularization flow index (VFI)) were caluculated in each fetus. Intraand inter-class correlation coefficients were used as an expression of reliability and intraand inter-observer agreements of measurements were caluculated according to the Bland-Altman test. P < 0.05 was considered significant. The research protocol was approved by the Ethics Committee of Kagawa University School of Medicine. Results: FBV was curvilinearly correlated well with the gestional age (R2 = 0.861, P < 0.0001). All 3DPD indices (VI, FI, and VFI) showed no change at 10–13 weeks’ gestation. In this study, good intraand inter-class correlation coefficients and intraand interobserver agreements were confirmed. Conclusions: Oure findings suggest that transvaginal 3DPD sonography may provide new information on the assessment of fetal brain volume and perfusion late in the first trimester of pregnancy.