P128 Transformation of breast fibroadenoma to ductal carcinoma in situ and malignant breast tumour

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Goals: To study the expression of 11b-hydroxysteroid dehydrogenase type1 in breast cancer and adjacent non-malignant tissue, and the correlations between the results and the clinical factors. Methods: We have studied the expression of the oxidative enzyme 11bhydroxysteroid dehydrogenase type 1 in 84 specimens of female human breast carcinoma and adjacent non-malignant tissues by immunocytochemistry. These results were correlated with the clinical parameters. Results: 11b-HSD1 was found in the cytoplasm of tumor cells in 66.7% of cases. In adjacent non-malignant tissues, all of the cases were positive and the enzyme was detected in the cytoplasm of epithelial cells of the acini and ducts. There was a significant difference between the malignant tissue and the adjacent non-malignant tissues in the percentage of positive cells in the enzyme (x2 = 7.7586, P=0.0053). In adjacent non-malignant tissues, the expression of 11b-HSD1 was significantly correlated with the age of patients (r = 0.34763, P=0.0134), menopause (r = 0.39859, P=0.0046), the expression of PR (X2 = 7.4871, P=0.0062) and ER (X2 = 9.0835, P=0.0026) in adjacent non-malignant tissues. For the other clinical parameters, there was no significant correlation found in cancer tissue or adjacent non-malignant tissue. Conclusion: In adjacent non-malignant tissues the expression of 11bHSD1 was significantly higher than in cancer tissue, moreover AR was the same as 11b-HSD1. It indicated the important role of 11b-HSD1 in the development and/or progression of breast cancer, and it also suggested the androgen may suppress the breast cancer proliferation through AR. The expression of 11b-HSD1 of postmenopause women was significantly higher than premenopause ones in adjacent non-malignant tissues, this indicated the changing of the androgen local synthesis in the postmenopause women. Disclosure of Interest: None Declared