P1276 Excess mortality associated with atrial fibrillation complicating tricuspid regurgitation

Abstract

Abstract Introduction There is limited data regarding the prevalence of Atrial Fibrillation (AFib) in tricuspid regurgitation (TR) patients. In addition the influence on mortality of AFib on TR patients is not well studied. In the current study we aimed to examine whether the prevalence of AFib is related to the severity of TR and to assess effect of AFib on the mortality of TR patients. Methods The cohort included 397 patients (mean age 77.1 ± 15.2 Years; 36.3 % males) with TR of any cause that underwent quantitative prospective evaluation by the PISA method for regurgitant volume and effective regurgitant orifice (ERO). The primary outcome was all-cause mortality. Results 251 (65.9%) of the patients were classified as mild to moderate TR (ERO < 0.4) and 130 (33.6%) patients classified as severe TR ( ERO≥ 0.4) The prevalence of AFib in the total cohort was 56.4%. The prevalence of AFib in the mild to moderate TR patients was lower than in the severe TR group (52.5% vs. 63.9%; p = 0.03). In univariate Hazard analysis atrial fibrillation was associated with increased mortality (HR = 1.18, P < 0.04). In sub-group analysis atrial fibrillation was associated with excess mortality in the mild and moderate TR group (Log Rank Chi square = 3.11, p= 0.07) but not in the severe TR group. Conclusions The prevalence of AFIB among TR patients is high, and severe TR is associated with higher prevalence of AFIB compared to milder disease. AFib is independently associated with mortality in patients with less than severe TR but not in the severe TR group. Abstract P1276 Figure.