P127 FACTORS ASSOCIATED WITH FECAL URGENCY IN INFLAMMATORY BOWEL DISEASE PATIENTS: A CROSS-SECTIONAL STUDY FROM SPARC IBD

Abstract

Abstract Background Fecal urgency among patients with inflammatory bowel disease (IBD) can lead to psychological, functional, and social distress. Factors associated with urgency remain poorly understood. Objective To examine the association between urgency and fecal calprotectin concentration, rectal bleeding, stool frequency, perianal disease, rectal involvement, and disease duration. Methods The results are based on data obtained from the IBD Plexus program of the Crohn’s & Colitis Foundation. This cross-sectional study used data from Study of a Prospective Adult Research Cohort with IBD (SPARC IBD), a multicenter longitudinal study. We included patients with an urgency score at their first study visit. Urgency was rated on a 5-point Likert scale from no to severe urgency. The Kruskal-Wallis test was used to compare fecal calprotectin levels across fecal urgency scores. Logistic regression models were used to evaluate the association of fecal urgency with the amount of rectal bleeding, stool frequency, perianal disease (for Crohn’s disease (CD)), disease involving the rectum (for CD), disease duration, while adjusting for age and gender in each model. Results 2289 patients were included (54% female, 67% CD, mean age 43). The fecal calprotectin concentration was significantly associated with fecal urgency scores (P-value= 0.01). In adjusted models of the overall population, CD vs UC was not associated with urgency (odds ratio [OR] 0.89; 95% confidence interval [CI] 0.70–1.13). Fecal urgency was associated with stool frequency (> 4 stools more than normal, OR 2.49; 95% CI 1.46–4.25) but not amount of bleeding. Among patients with CD, perianal disease (OR, 3.40; 95% CI, 1.18–9.79) was associated with fecal urgency. Conclusion In this study of patients in SPARC IBD, factors associated with fecal urgency were fecal calprotectin levels, stool frequency, and perianal disease.