Abstract
Background The V3 loop is a major neutralizing determinant of the HIV-1 virus. Cholera toxin subunit B (CTB) is a highly immunogenic protein and it has been used in fusion constructs to enhance immunogenicity of target proteins. We hypothesized that a rationally designed immunogen, based on V3 and CTB, could induce high titers of Abs with binding mode and epitope specificity similar to known broadly neutralizing anti-V3 mAbs.
Highlights
The V3 loop is a major neutralizing determinant of the HIV-1 virus
AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
Cholera toxin subunit B (CTB) is a highly immunogenic protein and it has been used in fusion constructs to enhance immunogenicity of target proteins
Summary
Structure-guided design and immunological characterization of immunogen constructs presenting the HIV-1. Address: 1M olsoft, La Jolla, CA, USA, 2NYU Langone School of Medicine, New York, USA, 3PHRI Center, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA and 4University of Massachusetts Medical School, Worcester, MA, USA. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P179 doi:10.1186/1742-4690-6-S3-P179. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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