Abstract
IDO1 has been identified as an immune checkpoint gene and play an important role in tumor immunosuppression. RT can influence IDO1 and IDO1 metabolites which were significantly correlated with metastatic risk and overall survival in patients with lung cancer treated with radiotherapy. However, the molecular mechanism of how RT influence IDO1 in lung cancer is still unknown. Some studies indicate that a high level of NO can suppress the IDO1 protein synthesis, and NO was mainly mediated by iNOS, which was highly expressed after RT.
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