P115 A segmental LPS challenge study to investigate the pharmacodynamics of a TRPV4 antagonist (GSK2798745) in healthy participants

Abstract

Introduction and objectivesAcute Respiratory Distress Syndrome (ARDS) is associated with increased pulmonary vascular permeability. In the lung, transient receptor potential vanilloid 4 (TRPV4), a Ca2+-permeable cation channel, is a known...