Abstract
Methods: Urine samples were obtained in 354 consecutive patients, referred to the department of rheumatology for one of the following diseases [Osteoarthritis (OA), rheumatoid arthritis (RA), ankylosing spondylitis (AS), undetermined inflammatory arthritis (UIA), osteoporosis (OP)] and in 66 controls (CTRL). CTX I and II were assayed using a competitive ELISA method. CTX I and II correlations were studied by linear regression. Differences in CTX levels between groups were studied with analysis of variance, taking into account age, sex and BMI. Results: Cross sectional study. 144 males and 276 females; mean (SD) age 59(17); mean CTX I 228.9 (204) ng/mL; mean CTX II 375.7(408.6) ng/mL. CTX I was significantly higher in females than in males (p=0.006). There was a correlation between CTX I and CTX II concentrations (R=0.34, p 0.2). Conclusions: Both CTX I and II were increased in muscoskeletal diseases. Compared to CTRL, CTX I levels were signifcantly increased only in patients with OP. By contrast CTX II were significantly increased in OA, inflammatory rheumatisms but also OP. Surprisingly CTX II was as high in OP as in inflammatory diseases and in OA. The influence of the treatments on CTX levels remains to be investigated.
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