P-1115 - Prevalence of conventional antipsychotic induced movement disorders and factors associated with them among psychotic patients treated at amanuel mental specialized hospital; aa, ethiopia

Abstract

Background Neuroleptic-induced movement disorders constitute a worldwide problem in the treatment of schizophrenia because of the limited affordability of atypical antipsychotic drugs. However, the prevalence of Neuroleptic-induced movement disorders and their associated factors have not been studied in psychotic patients in Ethiopia. Objective To determine the prevalence of conventional antipsychotic induced movement disorders and associated factors among psychotic patients at Amanuel mental specialized Hospital. Method Hospital based cross-sectional study was conducted by using established clinical rating scales to identify cases of conventional antipsychotic-induced movement disorders in Amanuel mental specialized Hospital samples of 377 psychotic outpatients. Systematic random sampling method was employed to select subjects. Logistic regression was used for comparison of the subjects with and without Neuroleptic-induced movement disorders. Findings and conclusions Neuroleptic-induced movement disorders according to the clinical rating scales were found in: 175(46.4%) had neuroleptic-induced Parkinsonism, 108(28.6%) had neuroleptic-induced Akathisia and 45(11.9%) had neuroleptic-induced tardive dyskinesia. Khat use AOR = 1.93, 95%CI: 1.01–3.66 was factors remained to be associated with the presence of NIA. Alcohol use AOR = 3.25, 95%CI: 1.04–10.16 was associated with TD. Being on chlorpromazine equivalent dose range of > = 400 mg/day AOR = 4.32, 95%CI: 2.25–8.30, AOR = 3.68, 95%CI: 1.81–7.48, AOR = 4.16, 95%CI: 1.17–14.83 were associated with Parkinsonism, Akathisia and TD respectively. In conclusion, many patients with psychotic disorders suffered from a conventional antipsychotic -induced movement disorder. Khat, alcohol and high dose of drugs were found to be associated with conventional antipsychotic Induced movement disorders.