Abstract
Background Vaccine-mediated prevention of primary infection with HIV likely requires the sustained production of antibody at mucosal portals of entry. We determined the dynamics of systemic and mucosal antibody production in macaques following a novel approach of repeat mucosal immunisation by delivery of trimeric recombinant HIV1 clade C gp140 in a gel formulated for vaginal delivery either alone or in combination with systemic immunisation via the intramuscular route using adjuvanted gp 140.
Highlights
Vaccine-mediated prevention of primary infection with HIV likely requires the sustained production of antibody at mucosal portals of entry
We determined the dynamics of systemic and mucosal antibody production in macaques following a novel approach of repeat mucosal immunisation by delivery of trimeric recombinant HIV1 clade C gp140 in a gel formulated for vaginal delivery either alone or in combination with systemic immunisation via the intramuscular route using adjuvanted gp 140
Cynomolgus macaques received either 3 rounds of repeat intravaginal immunisation with gp140 formulated in Carbopol® 974P polymer gel, followed by a single intramuscular immunisation with 100 μg gp140 in GSK Biologicals AS01b adjuvant (Group A); a single im immunisation alone (Group B), a single im immunisation followed by one round of ivag immunisation (Group C); or 3 im immunisations followed by one round of ivag immunisation (Group D)
Summary
Intravaginal administration of HIV-1ZM96 gp140 augments systemic and mucosal antibody responses following systemic priming with adjuvanted protein. M Cranage, C Fraser*1, A Cope, P McKay, W Elsley, M Page, AN Mahmoud, K DaCosta, P Fletcher, N Armanasco, N Almond and. Address: 1Centre for Infection, St George's University of London, London, UK and 2National Institute for Biologicals and Controls, Potters Bar, UK * Corresponding author from AIDS Vaccine 2009 Paris, France. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P151 doi:10.1186/1742-4690-6-S3-P151. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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