Abstract
non-tubular structures surrounded by hepatocellular parenchyma. COH length was measured as distance from limiting plates. Local context was recorded (budding ducts and cholestatic feathery degeneration of buds). Results: COH number was higher in non-biliary vs biliary disease (p < 0.0001) and vs controls (p < 0.0001). COH were longer in nonbiliary vs biliary disease (p < 0.0001) and controls (p < 0.0001). Budding correlates with COH number (p = 0.0026). Biliary disease was associated with feathery degeneration of bud structures (p < 0.0001). Conclusions: COH are increased in chronic liver disease. During regeneration, buds of hepatocytes arise from distal ducts, leaving remnants of these ducts that are dragged into nascent parenchyma as buds mature. These remnants have a morphology identical to COH. Low COH number and length in biliary disease may reflect bile duct loss and lack of bud maturation because of destruction by cholestatic feathery degeneration.
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