P11.12.B SEIZURES IN PATIENTS WITH BRAIN METASTASES FROM BREAST CANCER: RESULTS FROM A RETROSPECTIVE SINGLE-CENTRE STUDY

Abstract

Abstract BACKGROUND Seizures may be a symptom of brain metastases (BrMs) from breast cancer. Gross-total resection (GTR) is known to correlate with a better seizure control, while the impact of radiotherapy (RT) and chemotherapy (CT) still remains uncertain. In this study, we aimed to explore which clinical and molecular factors might affect seizure control in a cohort of patients with BrMs from breast cancer. Patients and METHODS We retrospectively included patients ≥18 with surgically resected BrMs from primary breast cancer treated in our Institution from 1991 to 2022. RESULTS We included 79 patients in the analysis. Thirty-three (41.7%) had a history of seizures. Seizures prevailed in patients < 50 vs ≥ 50 (59.0% vs 32.0%, p=0.021), and they were not associated with BrMs location, number, or morphology (cystic vs non-cystic; bleeding vs non-bleeding). Patients with low (score 0-1) vs high (score 2-3) STAT3 expression in the peritumoural reactive astrocytes (RAs) had a slightly higher incidence of seizures (50.0% vs 35.0%, p=0.337). Seizure incidence did not differ between HER2+, HR+/HER2- and TNBC patients. Seizures tended to be more common after non-GTR as compared with GTR (21.0% vs 11.0%, p=0.293). RT and CT did not affect seizure control. CONCLUSION Younger age was associated with a higher risk of seizures, whereas different molecular subgroups (HER2+, HR+/HER2-, TNBC) or STAT3 expression in the RAs were not. To our knowledge, this is the first real-life study investigating the correlation between seizures and clinical and molecular factors in patients with BrM from breast cancer.