Abstract
Background Mucosal anti-HIV immunity at the virus portal of entry is likely essential to protect against sexual transmission of HIV. While the female genital tract has some immuneinductive potential, responses elicited to vaccine antigens applied to the vaginal mucosae have been modest at best. Immunological linkage between nasal and vaginal MALT has been demonstrated in both mouse and man, suggesting that nasal vaccination may promote vaginal mucosal immunity. We used a novel transferrin receptor targeted vaccine conjugate to enhance delivery of a vaccinating antigen across the mucosal epithelial barrier and compared nasal with vaginal vaccination.
Highlights
Mucosal anti-HIV immunity at the virus portal of entry is likely essential to protect against sexual transmission of HIV
AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
While the female genital tract has some immuneinductive potential, responses elicited to vaccine antigens applied to the vaginal mucosae have been modest at best
Summary
JF Mann*, DS Miranda de Stegmann, K Klein, D Stieh, MP Cranage, RJ Shattock and PF McKay. Address: Infectious Diseases, SGUL, London, UK * Corresponding author from AIDS Vaccine 2009 Paris, France. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P154 doi:10.1186/1742-4690-6-S3-P154. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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