Abstract
Background: Ankle-brachial index (ABI) measured by conventional Doppler method has been reported to be an independent predictor of adverse cardiovascular events in patients with coronary artery disease (CAD). Recently, a clinical device has been developed to measure ABI by an oscillometric method. It is unclear whether ABI measured by this device can serve as a significant predictor of cardiovascular events in patients with CAD. Materials and Methods: We included 82 patients from our outpatient clinic, who had received coronary angiography examination. ABI was determined in all subjects using the ABI-form (Colin VP1000) device. The lower value of ABI in either of the right or left limbs was used for data analysis. We divided our subjects into two groupswitheitherABI0.9orABI0.9andcomparedbasalcharacteristicsbetweengroups.Wefollowedupthese patients for 20.0 3.6 months (range 10 to 26). We analyzed the relationship between ABI and cardiovascular events. Then, we used univariate analysis to determine the significant predictors of cardiovascular events. Finally, we utilized multiple logistic regression analysis to identify the independent predictors of cardiovascular events. Results: There were 14 patients with ABI 0.9 and 68 patients with ABI 0.9. The patients with ABI 0.9 were olderandhadhigherplasmalevelofuricacid.Theprevalenceofthree-vesselCAD,diabetesmellitus,hypertension, diuretic use, and the risk of cardiovascular death and cardiovascular events were significantly higher in the group of patients with ABI 0.9. In a univariate analysis, cardiovascular events were significantly related to ABI 0.9 (odds ratio: 12.6), three-vessel CAD (odds ratio: 12.5) and DM (odds ratio: 4.7). After a multiple logistic regression analysis, ABI 0.9 and three-vessel CAD were still significant predictors of cardiovascular events. Conclusions: ABI measured by the automated oscillometric method, like three-vessel CAD, can serve as a useful parameter to predict cardiovascular events in patients with CAD.
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