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Abstract
Abstract Background and Aims Peripheral arterial disease (PAD) is more often seen in diabetic patients, accounting for 25-30%. Diabetic patients suffered more lower limb amputations in Unites States as high as 60% and patients with PAD suffer higher risk for amputations. We want to use CHADS2 and CHA2DS2-VASc scores to predict the risk of PAD in diabetic patients. Method We analysed data from the Taiwan National Health Insurance Research Database between January 1st, 2002 and December 31st, 2009. A total of 5,6732 diabetic patients were selected as the study cohort. The CHADS2 score and CHA2DS2-VASc score were calculated for each patient. Results During the follow-up period, 228 (0.4%) patients experienced new-onset PAD. The rate of PAD increased from 0.3% (CHADS2 score 1-2) to 1.4% (CHADS2 score 4-6) (p<0.001). The rate of PAD increased from 0.2% (CHA2DS2-VASc score 1-3) to 3.5% (CHADS2 score 7-9) (p<0.001). According to a multivariate analysis, the hazard ratio of each point increment in the CHADS2 score for predicting PAOD was 1.67 (p<0.001), CHA2DS2-VASc score was 2.03(p<0.001). Conclusion The CHADS2 and CHA2DS2-VASc scores are useful predictors of new-onset PAD in diabetic patients.
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