P103. Relationship between severe preeclampsia onset with IUGR incidence at Dr. Soetomo General Hospital in 2013

Abstract

Introduction Intrauterine growth restriction can be a serious problem in neonates because it is associated with increased morbidity and mortality and long-term sequel in the future. One of the main maternal risk factors of intrauterine growth restriction is severe preeclampsia in pregnancy. As we know preeclampsia has two types, first is early onset of severe preeclampsia that caused by failed of trophoblast invasion to the spiral artery and the second is late onset of severe preeclampsia that caused by such as chronic hypertension, diabetes mellitus, obese, tuberculosis, SLE ( systemic lupus erythematosus) and other autoimmune disease. Objectives We are curious about relationship onset of severe preeclampsia with intrauterine growth restriction. This study analyzed the relationship between the onset of severe preeclampsia and the incidence of intrauterine growth restriction in Dr. Soetomo General Hospital Surabaya. The aim of this study was to prove whether early onset severe preeclampsia is a risk factor for intrauterine growth restriction compared with late-onset severe preeclampsia. Methods This was an analytic observational cross-sectional study. Sampling technique we used in this study was random sampling. The data in this study were taken from the medical records at the Department of Obstetrics and Gynecology Dr. Soetomo General Hospital Surabaya in January 2013 until December 2013, which include in these data are gestational age, preeclampsia onset, sex, birth weight, and intrauterine growth restriction incidence. The onset of severe preeclampsia was divided into two categories: first, early onset (⩽34 weeks) and second, late onset (>34 weeks). Data analysis was performed in two stages, the univariate and bivariate analysis. Data analysis used was cross tabulation and chi-square test with level of significance of 95% ( p Results Results showed that prevalence rate of IUGR in early-onset severe preeclampsia was 1.32 times higher compared with late-onset severe preeclampsia. However, there was no statistically significant association between early-onset preeclampsia and the incidence of IUGR. ( p = 0.53; PR=0.71; 95% CI = 0.25–2.07). Late-onset severe preeclampsia also had no effect on the incidence of intrauterine growth restriction ( p = 0.53; PR = 1.40; 95% CI = 0.48–4.08). Conclusion It can be concluded that the onset of severe preeclampsia had no effect on the incidence of intrauterine growth restriction.