P10.13 Outcomes in older patients referred with low grade glioma

Abstract

OBJECTIVES: To investigate the progression-free (PFS) and overall survival (OS) in patients ≥60 years old referred with a presumed diagnosis of low grade glioma (LGG). DESIGN: Neuro-oncology MDT outcomes from a single institution between 1/1/2009 and 31/12/2013 (n=7158) were retrospectively reviewed. Patients ≥ 60 years old referred with a presumed diagnosis of LGG were identified for further analysis (n=59). Where patients were still alive, overall survival was calculated up to 1/11/2016. Low grade lesions were defined as WHO grade I or II. METHODS: Data was collected from notes, electronic and summary care records for analysis to find index operation type, histology, radiological follow-up, MDT discussion, adjuvant treatments, any re- operations and dates of death. PFS and OS were calculated from this information. Results: Of 59 patients referred with presumed low grade lesions, 40 had a LGG confirmed at biopsy; 9 had a high or intermediate grade tumour identified at biopsy; 7 patients did not have a biopsy and 3 patients had an alternative diagnosis made at biopsy. Median PFS for patients with confirmed LGG was 27.2 months (range 0.1-172.8) and median OS was 36.5 months (range 0.1-222.3). 5-year survival rate in this group was 40.0% (95% CI 23.8-56.2%). In patients with intermediate and high grade tumours, median OS was 12.5 months (range 2.8-52.3) and 5-year survival rate was 11.1% (95% CI 0.5-49.3%). Conclusions: This study suggests that survival rates in older patients with LGG are significantly lower than in younger age groups, and supports the possibility of a different and more aggressive pathology.