Abstract
Background During acute HIV infection (AHI), CD4+ T cells undergo apoptosis from direct infection and through bystander apoptosis induced by inflammatory factors. Both the inflammatory factors and apoptotic material produced during AHI may negatively impact innate and adaptive immune responses. Such inhibitory factors present in AHI plasma include apoptotic microparticles (MPs), small membranous blebs derived from dying cells. Dendritic cells (DCs) are the sentinel cells of the immune system that respond to pathogens, frequently through Toll-like receptor (TLR) recognition of unique pathogenic macromolecules. Because TLR recognition of viral material by DCs is important for DC priming of virus-specific T cells, we determined how AHI patient plasma or apoptotic MPs affect TLR-stimulated DCs.
Highlights
During acute HIV infection (AHI), CD4+ T cells undergo apoptosis from direct infection and through bystander apoptosis induced by inflammatory factors
Dendritic cells (DCs) are the sentinel cells of the immune system that respond to pathogens, frequently through Toll-like receptor (TLR) recognition of unique pathogenic macromolecules
Because TLR recognition of viral material by DCs is important for DC priming of virus-specific T cells, we determined how AHI patient plasma or apoptotic MPs affect TLR-stimulated DCs
Summary
Address: 1Cancer Institute, New York University Langone Medical Center, New York, USA, 2Duke University Medical Center, Durham, NC, USA and 3Oxford University, Oxford, UK. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P136 doi:10.1186/1742-4690-6-S3-P136. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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