P10.05: Nitric oxide donors and fluid therapy increase fetal growth in gestational hypertension

Abstract

Objective: Adding NO donors to the antihypertensive treatment in gestational hypertensive patients complicated by fetal growth restriction. Methods: Fifty moderate to severe gestational hypertensive patients (27–30 weeks of gestation) with fetal abdominal circumference < 10th percentile for gestational age and normal fetal Doppler parameters, were submitted to maternal echocardiographic exam before and 14 days after treatment was started. Patients were randomised in two treatment groups: (1) 25 patients underwent Calcium antagonists and Bed Rest; (2) 25 patients underwent Calcium antagonists and Bed Rest + Transdermal glyceryl trinitrate (5–10 mg released in 24 hours administrated for 12–14 hours) + intravenous fluid infusion with 2000 mL over 24 hours. Results: Are shown in the table. Conclusions: Nitrates and fluid therapy added to standard antihypertensive treatment improve maternal hemodinamics and fetal growth more than standard antihypertensive treatment alone.