P1. Setting up the internal quality control of a F18 automatic sampler following the ordinance of 2008

Abstract

Introduction The radiopharmaceutical laboratory of Avicenne Hospital has acquired in October 2015 automatic drug dose radiopharmaceutical labeled sampler Unidose® F18 at the Trasis brand. This system realises individual dose that will be injected into patients. It must therefore be controlled according to the order of 25 November 2008 laying down the procedures for quality control of nuclear medicine facilities. Methods The automatic sampler Unidose has two measurement areas: one for the tank that contains all received drug activity and an individual patient’s dose contained in a cartridge. Both systems were calibrated by CERCA LEA geometries measures used routinely. For each system, we will realize the internal control defined in item 5 of the ordinance of 2008, namely the fidelity of the measure, the reproducibility of the measurements, the volume of isosensibility and linearity. Results Part of quality control of Trasis system is partially automated (or set in the system), it is necessary first to define the constant sources in the software. For the first measurement area that is to say the tank, measure of accuracy, reproducibility and linearity show results conform to acceptability criteria. The volume of isosensibility is 3.5 cm between the vertical distance of 0.5 cm and 4 cm. For the second measurement system that determines the injected patient dose achieving quality controls following the ordinance of 2008 is more complex because the measurement system is not well ionisation chamber. The fidelity of measurement and reproducibility show results conform to acceptability. The evaluation of the system response linearity and determining the volume of isosensibility are ongoing. Conclusion Our feedback shows all the particularity of these fully automated systems and the limits of regulation. Indeed the use of a measuring system accessible with difficult and that is not an ionization chamber well confronts us with difficult steps following the ordinance of 2008.