P1 Amplitude Across Replicates

Abstract

Most cortical auditory evoked potentials instruments provide a "default" peak-to-baseline (P-B) amplitude and a means for obtaining a peak-to-trough (P-T) measure. This study investigated the sensitivity of these two measures in assessing the effects of repeated runs on the P1 component of the electrophysiological response. Cortical auditory evoked potentials were recorded on 30 normal hearing young adults. Three stimuli were used: an 80-millisecond synthetic /da/ and a 1 kHz tone burst of 40- and 80-millisecond durations. Stimuli were presented at 60 dB normal hearing level in a counterbalanced order. Three serial replicates were obtained for each stimulus. P1 amplitude and latency were measured. The P-T amplitudes diminished significantly (P < 0.01) from replicate 1 to replicate 3 for each of the three stimulus types, but P-B amplitudes did not. P1 latency findings were consistent with effects shown by diminished P-T amplitude data in which latency increased significantly (P = 0.024) from replicate 1 to replicate 3 for one stimulus (40-millisecond tone). The P-T amplitude measurement method identified significant decrements in amplitude because repeated runs were obtained, whereas the P-B method did not. These findings suggest that a P-T method is more sensitive to some P1 electrophysiological activity than is a P-B measure.