Abstract
A primary outcome measurement for evaluating efficacy in clinical trials of Duchenne muscular dystrophy (DMD) is strength. Because of the challenges of measuring strength, the Cooperative International Neuromuscular Research Group (CINRG) adapted a fixed system called the CINRG Quantitative Measurement System (CQMS). A non-fixed method is a Hand-Held Myometry (HHM) device, by Microfet. This study compared the intra and inter rater reliability of these two methods in order to assess which of the two quantitative muscle testing systems is more reliable for future DMD clinical trials.
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