P1-3-2 - Role of Chemotherapy in Stage II Nasopharyngeal Carcinoma Treated with Curative Radiotherapy

Abstract

Purpose: To define the role of chemotherapy (CT) in stage II nasopharyngeal cancer (NPC), we analyzed the treatment outcomes of those patients treated with curative radiotherapy (RT) with or without CT.Patients and methods: From 2004 to 2011, 138 patients with AJCC 2002 stage II NPC were treated with curative RT in 12 hospitals in South Korea. Various treatment methods were used; RT alone in 34 patients, neoadjuvant CT followed by RT alone in 7, concurrent chemoradiotherapy in 80, and neoadjuvant CT followed by concurrent chemoradiotherapy in 17. Adjuvant CT was used in 42 patients. Total radiation dose ranged from 64 Gy to 74.2 Gy (median, 70 Gy).Results: Median follow-up period was 48 months (range, 7-97 months) for all patients. Until the last follow-up, 13 patients had died and 32 had experienced failures; locoregional failures in 14 patients, distant failures in 16, and both in 2. Five-year locoregional relapse-free survival (LRRFS), distant metastasis-free survival (DMFS), progression free survival (PFS), and overall survival (OS) were 86.2%, 85.5%, 74.4%, and 88.2%, respectively. In multivariate analyses, significant prognostic factors were concomitant CT for LRRFS, age and concomitant CT for PFS, and age for OS, respectively. Neither neoadjuvant nor concomitant CT improved DMFS.Conclusions: Concomitant CT significantly improved LRRFS and PFS in stage II NPC, although neoadjuvant CT did not improved PFS.