P1-280: Amyloid and glucose metabolism in early versus late-onset Alzheimer's disease: A comparative [11C]PIBand [18F]FDG PET study

Abstract

each participant was reviewed by a panel of neuropsychologists and neurologists, to establish a diagnosis of cognitively normal, MCI, or dementia. Plasma CRP was measured from a blood draw performed at baseline using immunoassays. Results: The median age of subjects was 80 years (interquartile range: 75 84) and 51% were men. We compared patients with MCI (N 313) with cognitively normal subjects (N 1,570), and adjusted the analyses by sex, age, and education (as continuous variables). A CRP level in the upper quartile ( 0.33 mg/dl) was significantly associated with MCI of all types (odds ratio [OR] 1.42, 95% confidence interval [CI] 1.00, 2.01), and with non-amnestic MCI (OR 2.05, 95%CI 1.12, 3.77), but was not associated with amnestic MCI (OR 1.21, 95%CI 0.81, 1.82). With additional adjustment for conventional vascular risk factors (current cigarette smoking, diabetes and hypertension; ever vs. never) and history of coronary heart disease and stroke (ever vs. never), we observed a marginal association of CRP 0.33 mg/dl with MCI of all types (OR 1.40, 95% CI 0.98, 2.00), but the association with non-amnestic MCI remained statistically significant (OR 1.88, 95% CI 1.01, 3.51). Conclusions: Our study findings suggest that plasma CRP is associated with prevalent non-amnestic MCI in elderly non-demented persons. This association suggests that inflammation may have a role in the pathogenesis of non-amnestic MCI.