Abstract
McMillan and Teasdale showed in a prospective seven-year follow-up study of patients with mild traumatic brain injury (MTBI) significantly increased mortality rates with up to 7-times higher risk of mortality than in the average population [1]. The pathomechanisms causing increased death rates are unknown but might be related to central autonomic dysregulation due to the brain injury. Clinically overt signs or symptoms of autonomic dysfunction may be missing after MTBI. However, maneuvers activating the central autonomic modulation, such as orthostatic challenge with baroreflex activation, might unveil mild centrally caused autonomic dysfunction after TBI.
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