Abstract
Acute Lymphoblastic Leukemia (ALL) is a clonal expansion of hematopoietic blast, a highly heterogeneous disease with many entities that build up from genetically heterogeneous lymphoid neoplasms derived from B- and T-lymphoid progenitors. ALL is the most common cancer in children. Relapse of ALL is the leading cause of death, however the cause of relapse itself is poorly understood, thus this systematic review aims to summarize and determine the correlation between the existence of mutations in CREBB protein in ALL and the risk of relapse.
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