Abstract
A key issue in lung screening is how to identify low-risk individuals who could safely undergo the next scheduled screening CT in 2 years instead of annually and the small proportion of participants who may benefit from more frequent screening for biologically aggressive tumours. In the International Lung Screening Trial (ILST), after the baseline LDCT, participants were triaged to biennial or annual repeat screening, early recall CT scan in 3 months or diagnostic work-up referral based on lung cancer risk (Ann Am Thorac Soc.
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