P1.03-011 Clinical Characters of 19 Bronchial Asthmatic Patients with Lung Cancer

Abstract

To investigate the clinical features of lung cancer among asthmatic patients. Retrospectively analyzed the clinical characteristics of 19 patients with bronchial asthmatic and lung cancer that were treated by the second hospital of Jilin university from 2009 to 2015. The morbidity of lung cancer in bronchial asthma patients accounted for 1.4% of the patients in our hospital. All patients were older than 40 years old, among which 11 (58%) were over 60. Cough and expectoration were the major clinical symptoms which occurred in 14 cases(74%). According to the pathological results, 4 cases were squamous cell carcinoma(21%), 7 were small cell carcinoma (37%), 7 were adenocarcinoma(37%), and only 1 case were poorly differentiated non-small cell carcinoma (5%). In the small cell lung cancers, the primary cancer in 5 cases were still at limited stage, in 2 cases had developed into an extensive tumor. In non-small cell lung cancers, there were 2 cases at stage II, 2 cases at stage IIIa, 7 cases at stage IIIb and 1 cases at stage IV. From the chest CT performance, the patchy and mass like nodules were recognized as the main manifestations. In all the 19 patients, manifestations of asthma were not effectively managed. In 10 of the patients, the PS score was poor and did not receive any anti-tumor treatment, while other 9 cases received anti-tumor therapy. Bronchial asthma, especially those being not well controlled, is a potential risk factor for lung cancer. Lung cancer should be aware in the acute episode of asthma. For asthma exacerbation in patients over 60 years old, the chest CT scan is a recommended choice, or regularly reviewed by low dose CT screening to discover lung cancer at early stage and improve prognosis. But the anti-tumor therapy of severe asthma combined with lung cancer patients is still a difficult problem.