P1.01-037 Baseline Demographics and Comorbidities of Patients with Advanced NSCLC Compared to the General Population from Two Regions in Sweden

Abstract

Lung cancer is the most commonly diagnosed cancer in men and the third most common in women. However, detailed analyses of patient newly diagnosed with advanced non-small cell lung cancer (NSCLC) in routine clinical care, compared to the general population, is limited. This non-interventional study is based on existing data from the population-based national Swedish Cancer Registry. All adult patients diagnosed with advanced NSCLC between 2006 and 2013 receiving care in the regions of Skåne and Västra Götaland counties (about 37.6% of NSCLC patients in Sweden) were included and matched (1:4) by age at diagnosis, gender and region of residence to a sample from the general population (controls). In- and outpatient visit data was extracted from regional databases in order to assess prevalence of selected baseline comorbidities detected in the year before diagnosis. In total, 4,758 patients with advanced NSCLC were identified and matched to 18,996 controls. At the date of the initial NSCLC diagnosis, the median age was 69.0 (range 22-97; 96.2% above 50), and 52.7% were men. The stage of disease was IIIb in 19.8% (n=944) or IV in 80.2% (n=3,814) of the patients. When specified, adenocarcinoma was the most frequent histology (70.4%) followed by squamous cell carcinomas (25.4%). A total of 50.9% of the NSCLC patients had recorded morbidities in the year preceding the diagnosis compared to 34.8% of the controls (Odds Ratio (OR) 1.94; P<0.001)). Patients with advanced NSCLC had significantly more often (P<0.001) respiratory disorders (16.4% vs. 3.2%; OR 6.02), infections (13.4% vs 6.1%; OR 2.37), anaemia (3.4% vs. 1.7%; OR 2.08), musculoskeletal disorders (3.7% vs. 2.5%; OR 1.51), and cardiovascular disease (27.8% vs. 22.7%; OR 1.31). No significant difference was observed in prevalence of gastro-intestinal disorders, metabolic disorders or skin disorders. Regarding disorders of the central nervous system, while depression was more frequently present among NSCLC patients (3.8% vs. 2.8%; OR 1,38) dementia was more prevalent among controls (0.6% vs. 1.2%; OR 0.48). As expected, brain metastasis was diagnosed overwhelmingly more for NSCLC patients (53 cases, vs. 2 cases; OR 107.0). The present study suggests that patients diagnosed with advanced NSCLC have a significantly higher morbidity burden than the general population in these regions in Sweden.