P-096: Measure of change in carotid-radial pulse wave velocity after reactive hyperaemia

Abstract

Background The recognized reference method for endothelial function assessment is brachial artery diameter echo-tracking during flow mediated dilation (FMD) induced by reactive hyperaemia (RH). From the Mons-Korteweg equation, FMD should also reduce upper limb pulse wave velocity (PWV). The aim of our study was to compare echo-tracking FMD with PWV changes after RH. Methods Brachial diameter was assessed by echo-tracking (MyLAb 70, Easote, Italy) before and after 7 min of ischemia induced by inflating a cuff on the right wirst 50 mmHg above subject's systolic blood pressure. Carotid-left radial and carotid-right radial PWVs were also simultaneously measured with Complior Analyse (Alam Medical, France) at baseline (in triplicate), 30s, 1, 3 and 5 min end of ischemia. Measurements were performed in 15 healthy subjects (10M/5F, 31 ± 11 yrs). Results Maximum PWV changes happened 1 min after cuff deflation in the ischemic arm (δPWV=2,1±1,4 m/s, p The maximal change in arterial diameter post-RH was 5,1±4,7%. There was no correlation between diameter change and δ PWV (R=0,03, p=0,91). Conclusions While the use carotid-radial PWV seems promising to track changes post RH, further studies are needed to better understand this phenomena which is not related to diameter change. Download : Download high-res image (71KB) Download : Download full-size image Abstract P-096 – Figure