Abstract
Introduction: The most common breast cancers in postmenopausal women are hormone receptor-positive tumours, and hence, the majority of these women will be expected to take Aromatase Inhibitors (AIs) as part of their management. Up to 50% of post-menopausal breast cancer survivors taking AIs experience AI-associated arthralgias, or joint pain. This is a common side-effect leading to many patients stopping their AIs. This is the most common reason for the poor adherence to AIs. Physical exercise has been reported to improve tolerance to AIs, and therefore the authors conducted a systematic review of the medical literature to investigate the effectiveness of this treatment.
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