P09.02 Modular P329G-binding CAR T cells engineered to recognize human effector-silenced antibodies carrying a P329G Fc-mutation for targeting of solid tumor antigens

Abstract

BackgroundChimeric antigen receptor (CAR) T cell therapy revolutionized the treatment of patients with B cell and plasma cell malignancies. However, treatment success is still limited by treatment-associated toxicities and antigen-negative...