P09.51 Lung Adenocarcinoma in Morocco

Abstract

Lung cancer is the most common cancer and the leading cause of cancer death worldwide. Adenocarcinoma has become the most prevalent histological type. It represents about 60% of non-small cell lung cancers, and mainly related to changes in cigarette composition. This study aims to describe the epidemiological characteristics of lung adenocarcinoma in Rabat (capital of Morocco). This is a descriptive retrospective study of 162 cases of primary lung adenocarcinoma diagnosed and treated at Ibn Sina University Hospital Center in Rabat between January 2016 and December 2017. Of the 265 cases of primary lung cancer reported during the period of study, 162 (61.1%) were diagnosed with adenocarcinoma. Of these, 88.3% were men, with a male-female ratio of 7.5. The average age at diagnosis of lung cancer was 59.2 years (range 31-80 years). Nearly one-fifth (19.6%) of patients were aged less than 50 years, 54.2% were between 50 and 65 years and 26.2% were older than 65 years. According to the results, 86.7% of men and 15.8% of women were smokers. Immunohistochemistry was performed on 132 cases. All patients were considered positive for cytokeratin 7 (CK7) but negative for cytokeratin 20 (CK20) and 82.3% were positive for Thyroid Transcription Factor-1 (TTF-1). The majority of cancer cases (81.5%) were diagnosed with locally advanced or metastatic disease. The increasing incidence of lung adenocarcinoma is alarming. Most cases were diagnosed with metastatic disease and occurred among smokers,highlighting the need for smoking cessation and lung cancer early detection programs.