Abstract
P09-19 LB. CTL escape mutations in gag epitopes restricted by protective HLA class I alleles cause substantial reductions in viral replication capacity
Highlights
Open AccessCTL escape mutations in gag epitopes restricted by protective HLA class I alleles cause substantial reductions in viral replication capacity
CD8+ T cell responses, those targeting Gag epitopes, play a critical role in the control of HIV during early infection, but the capacity of HIV to rapidly escape from such responses can undermine effective CTL-mediated control
CTL escape mutations in gag epitopes restricted by protective HLA class I alleles cause substantial reductions in viral replication capacity
Summary
CTL escape mutations in gag epitopes restricted by protective HLA class I alleles cause substantial reductions in viral replication capacity. Address: Ragon Institute of MGH, MIT, and Harvard University, Boston, USA * Corresponding author from AIDS Vaccine 2009 Paris, France. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P399 doi:10.1186/1742-4690-6-S3-P399. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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