Abstract
Background Spontaneous control of HIV to <50 copies RNA/ml is observed in rare individuals. An improved understanding of this phenomenon may provide insight into host mechanisms that can be modulated for therapeutic benefit by vaccines. Recent studies of these 'elite' controllers (EC) revealed HLA-associated changes in Gag-Protease that resulted in reduced replication capacity. This project assessed the possibility of immune-mediated defects in the Pol gene (RT-Integrase) of EC.
Highlights
Spontaneous control of HIV to
Similar results were observed between B51+ EC (N = 4) and B51+ progressors (N = 10) (p = 0.024), but not between B27+ EC (N = 9) and B27+ progressors (N = 5) (p = 0.437)
The association between fitness and expression of certain HLA that present Pol epitopes suggests that immune-mediated mutations impairing viral fitness may play a key role in spontaneous control of HIV
Summary
Reduced replication capacity of NL4-3 chimeric viruses encoding RT-Integrase sequences from HIV-1 elite controllers. Address: 1Ragon Institute of MGH, MIT, and Harvard, Boston, MA, USA, 2Institute of Medical Science, University of Tokyo, Tokyo, Japan, 3Microsoft Research, Redmond, WA, USA and 4Howard Hughes Medical Institute, Chevy Chase, MD, USA. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P124 doi:10.1186/1742-4690-6-S3-P124. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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