P0826OBESITY AND RISK FOR CHRONIC KIDNEY DISEASE IN THE HEALTHY MIDDLE-AGED KOREAN POPULATION

Abstract

Abstract Background and Aims Although obesity is a well-known risk factor for chronic kidney disease (CKD), previous epidemiologic studies have produced mixed results. This study was purposed to investigate the relationship between obesity and CKD occurrence in the healthy middle-aged Korean population. Method We used a prospective, longitudinal data from the Korean Genome and Epidemiology Study (KoGES), a population-based, epidemiology study in South Korea (2001-2014). A total of 6,678 participants aged 40-69 who were free of diabetes, hypertension, and CKD at baseline were followed-up biennially. CKD was defined as at least two-time occurrence of estimated glomerular filtration rate < 60 mL/min/1.73m2 using CKD-EPI equation during the follow-up period. Results A total of 433 participants (6.5%) developed CKD. We divided the participants into 5 groups by BMI: underweight (BMI < 18.5), normal-weight (BMI 18.5-22.0), overweight 1 (BMI 23.0-24.9), overweight 2 (BMD 25-29.9), and obesity (BMI >30). Compared to the normal-weight group, hazard ratio of CKD occurrence was elevated in overweight 2 (HR=1.43, p=0.01) and obesity (HR=1.73, p=0.03) in multivariate-adjusted regression analysis (variates: age, newly developed hypertension, newly developed diabetes, fasting glucose > 126mg/dL, 2hours glucose > 200mg/dL, systolic blood pressure > 140mmHg, physical activity, alcohol consumption, smoking). When dividing the participants into three age groups: the 40s, 50s, and 60s, only the 60s group showed a significant correlation of BMI with CKD occurrence (overweight 2: HR=1.93, p=0.05, obesity: HR=3.94, p=0.03). Conclusion The risk of CKD was significantly high for those in their 60s who were overweight or obese despite free of underlying diseases in the Korean population.