Abstract
Introduction: Propofol is widely used in anaesthesia for short procedures but there is limited evidence for its use in children undergoing endoscopy. The aim of this pilot study was to investigate the efficacy and safety of propofol as a single agent anaesthetic agent for paediatric gastrointestinal endoscopy without endotracheal intubation. We compared this with our current practice of conscious sedation using low dose midazolam and pethidine Methods: A prospective randomised trial with two groups in parallel was performed on 49 children. Entry criteria were all children deemed to be safe for deep sedation endoscopy. 32 patients (age 1.1 -15 years median 6.4 yrs) were given midazolam (0.1–0.2mg/kg) /pethidine (1–2mg/kg). 17 children (1.5 to 14 yrs, median 7.2 yrs) were recruited to have propofol anaesthesia. A single observer carried out the observations in the table Results: 16 out of 17 children tolerated the procedure under Propofol of 3–6 mg/kg. 1 child needed a maximum of 9mg/kg. Airway support was unnecessary. See table 1.Table 1Conclusion: Our data shows that anaesthesia with Propofol without tracheal intubation is safe. It is well tolerated by patients and provides excellent sedation for efficient endoscopic evaluation with short recovery times.
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