P07-F Event related EEG brain oscillations differentiate cognitive decline in patients with Parkinson’s disease

Abstract

Background Studies on Event Related EEG Brain Oscillations presented essential results on the understanding of cognitive brain function and cognitive decline in different pathologies. Event related oscillatory dynamics in Parkinson’s disease (PD) have not been studied comprehensively. In the last three years, our group aimed to fulfill this critical gap. Material and methods 27 PD patients without cognitive deficits, 34 PD patients with Mild Cognitive Impairment, 22 patients with PD Dementia and 33 healthy controls were included in the study.EEG was recorded during visual and auditory oddball paradigEvent related power spectrum, phase locking, event related coherence were evaluated in delta, theta, alpha, beta and gamma frequency bands for all group of subjects. Results Event related delta, theta, alpha and beta power and phase locking increased with a cognitive load in healthy subjects but these responses decreased in PD patients who have mild cognitive impairment and dementia. Event related delta, theta, and alpha coherence values were also lower in PD patients with cognitive deficits. The most differentiated results were found in the theta frequency band, frontal theta responses were the lowest in PD patients with dementia especially during the visual paradigm rather than the auditory paradigm. Conclusions Comprehensive analysis of Event-related oscillatory dynamics could successfully differentiate the cognitive decline in Parkinson’s disease patients. The differentiation between subject groups did not just appear in local circuits, but long distance connections were also impaired in PD patients with cognitive decline. Acknowledgments This work (Grant No. 214S111 ) was supported by TUBITAK .