P0757THO ROLE OF MARKERS TO ASSESS RISK FOR DEVELOPING CARDIORENAL SYNDROME

Abstract

Abstract Background and Aims Biomarkers are circulating proteins and metabolites, which are released in the body fluids from the damaged organ or tissue is detected specific essays and plays a role in the diagnosis, evaluation and monitoring of patients. Today there is a large number of markers that assess the intensity of pro-inflammatory and oxidative processes in the cardio-renal syndrome, whose determination would have great diagnostic and prognostic significance. The aim of our investigation was to identifying which of the examined parameters stand out as independent risk factors for the development of the cardiorenal syndrome (CRS). Method The study included 114 subjects older than 18 years, of both sexes, divided into clinical and control group. The control group was consisted of 35 healthy males and females with similar characteristics as well as clinical groups. The clinical group was consisted of 79 patients: 40 (50.63%) male and 39 (49.37%) female, mean age of 70.72 ± 9.26 years, diagnosed on the basis of the current classification of cardiorenal syndrome. The respondents were familiar with the case studies and signed informative consent. The study was approved by the Ethics Committee and conducted in compliance with the Helsinki Declaration on Medical standards of Good Clinical Practice. Results With correlation analysis of examined biomarkers in respondents of the clinical group was established positive correlation between plasma BNP and IL-8 (r = 0.383, p = 0.006), BNP and cTnhsT (r = 0.518, p = 0.001) BNP and cystatin C (r = 0.447, p = 0.001) and BNP and CRP (r = 0.306, p = 0.046), while a negative correlation was observed between the BNP and the activities of MDA (r = - 383, p = 0.007). Negative correlations were also between the activity of the MDA and the IL-8 concentration (r = -0.237, p = 0.038), and MDA cTnhsT (r = -0.321, p = 0.009) and MDA and cystatin C (r = -0.315, p = 0.005 ). XOD activity cost was positively correlated with the XD (r = 0.942, p <0.001), and the activity of XO was positively associated with TnI (r = 0.522, p = 0.009) and negatively correlated with the XD (r = -0.423, p <0.001 ). The concentration of IL-8 was positively associated with cTnhsT concentrations (r = 0.427, p <0.001) and with concentrations of CRP (r = 0.411, p = 0.001), the concentration of PAI-1 with cTnhsT concentration (r = 0.558, p <0.001), with TnI concentration cTnhsT (r = 0.852, p <0.001), and cTnhsT with cystatin C (r = 0.338, p = 0.006) and CRP (r = 0.358, p = 0.011). Cystatin C stood positively related to the concentration of CRP (r = 0.510, p <0.001). Conclusion Early detection of occurrence of functional and structural damage to the heart and kidneys, highly sensitive and specific markers would enable not only their discovery, but also prevention and treatment.