Abstract
Aim For the modernization of its Search & Match Service started in 2016, Bone Marrow Donors Worldwide (BMDW) envisaged to utilize an established HLA matching algorithm. The OptiMatch® search engine for the probabilistic matching of volunteer unrelated stem cell donors to patients in need of transplant was introduced by the German National Bone Marrow Donor Registry (ZKRD) in 2006. In the subsequent years, the core parts of OptiMatch® were isolated into a deployable stand-alone matching service called OptiMaS (OptiMatch® as a Service). OptiMaS has been used in the production environments of the Canadian OneMatch registry since 2012 and of the Australian Bone Marrow Donor Registry since 2013 and has meanwhile demonstrated to be a sound option for registries to benefit from the advantages of the OptiMatch® matching service locally. Methods In addition to the OptiMatch® search engine, the OptiMaS framework uses solely open-source software. Altogether, OptiMaS is a black box computer giving access to the capabilities of OptiMatch® via a small set of high-level web service functions. It fully supports the EMDIS matching preferences and is compliant with the WMDA HLA Nomenclature Guidelines. Results For this study, we have investigated the live system’s performance for 60 consecutive days as well as for a complete recalculation of the search reports for all patients. The analysis is based on over 29 million donors and cord blood units and on over 4000 for the daily and over 3000 patients for the complete calculation. We have focused on average matching times for typical search settings and highlighted special constellations leading to extreme (low and high) system burden. We have also studied the effects of input parameters on parallel processing. Daily average match time is 2 min with 50% of the searches returning within 25 s on a machine with 4 dedicated matching processes. Conclusions OptiMaS has shown for two representative scenarios to provide an appropriate matching service for BMDW’s global patient and donor load.
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