Abstract
Objectives Sound-induced flash illusions (SIFI) depend on visual cortex (V1) excitability [1]. In adults with migraine, in response to visual-acoustic illusions, V1 is hyperexcitable [2]. Susceptibility to SIFI is increased in children than adults. During childhood there is a change in sensory dominance: acoustic dominant switching to a visual [3]. Here we used SIFI to evaluate V1 excitability in children with migraine assessing also age-related differences in cross-modal audio-visual perception.
Highlights
Children with migraine did not differ from age matched controls in the illusory percept of fission or fusion, but they perceived more flashes (p < .05) in multiple flash trials with or without beep
The increased number of Sound-induced flash illusions (SIFI) seen by children is likely due to the higher propensity of visual stimulation driven by auditory stimulus, probably because of acoustic dominance typical for the age
The sound-induced flash illusions proved to be a valid tool for testing the visual cortical responsivity in pediatric migraine
Summary
Sound-induced flash illusions (SIFI) depend on visual cortex (V1) excitability [1]. In response to visual-acoustic illusions, V1 is hyperexcitable [2]. Susceptibility to SIFI is increased in children than adults. During childhood there is a change in sensory dominance: acoustic dominant switching to a visual [3]. We used SIFI to evaluate V1 excitability in children with migraine assessing age-related differences in cross-modal audio-visual perception. Materials Twelve children (7 females) affected by migraine without aura: mean age: 10.17±2.76 years, disease duration: 2.91 ±2.34 years and frequency of attacks: 4.17±3.76/months. Fifteen healthy children (11 females), mean age 10.61±2.92 years and twenty-four healthy adults (12 females), mean age 25.12±5.74 years with no familiarity for migraine. All subjects were not taking any drugs known to affect cortical excitability.
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