P0701LONG-TERM RETROSPECTIVE OBSERVATION STUDY TO EVALUATE EFFECTS OF ADIPONECTIN ON SKELETAL MUSCLE IN KIDNEY TRANSPLANT RECIPIENTS

Abstract

Abstract Background and Aims Although it is reported that chronic kidney disease participates some roles in progression of sarcopenia, mechanisms of the progression of sarcopenia are unclear so far. In this observational study, we focused on serum adiponectin levels, that is a marker of metabolic syndrome, cardiovascular disease, and skeletal muscle mass in patients with kidney transplantation. Method Fifty-one patients who underwent renal transplantation at our hospital in and after 1998 (31 males and 20 females; aged 29-52 years at the time of transplantation) were retrospectively examined the relationships between the psoas muscle index (PMI), intramuscular adipose tissue content (IMAC), serum adiponectin fractions (high-/low-molecular-weight), and new-onset diabetes after transplantation (NODAT). Results Age at kidney transplantation negatively correlated with PMI before transplantation and positively correlated with IMAC before transplantation (rS=-0.427, p<0.01; rS=0.501, p<0.01, respectively). Both in one and five years after transplantation, PMI was higher than before transplantation (p<0.01). In contrast, IMAC transiently decreased one year after kidney transplantation, but subsequently recovered five years after kidney transplantation. Multivariate analyses identified that the mean increases of high-molecular-weight adiponectin concentrations was exacerbating factor for the mean change in PMI (p=0.003). Moreover, the mean increases of PMI and IMAC were exacerbating factors for the newly development of post-transplantation diabetes mellitus. Conclusion PMI increased associated with high-molecular-weight adiponectin levels after renal transplantation. In addition, PMI increased suppressed the development of NODAT.