Abstract
2-fold higher in human breast carcinomas compared to matched normal breast tissue. Protein expression of the Na/H-exchanger NHE1 (SLC9A1) was markedly less affected. Conclusion: We demonstrate that upregulation of Na+,HCO−3 cotransport during human breast carcinogenesis contributes to the characteristic acid distribution within human breast carcinomas and propose that NBCn1 is a new possible target for early breast cancer therapy. Disclosure of Interest: No significant relationships.
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