P07.23: Cardiac troponin I in pregnancy complicated by IUGR, fetal distress and cardiac problems

Abstract

Troponin I (TnI) is a highly specific marker of myocardial injury. The aim of the study was to evaluate the prognostic value of cord blood TnI in SGA newborns, cardiac problems (arrhythmia, structural defects) or abnormal results of prenatal biophysical tests (abnormal Doppler flow velocimetry, computerized cardiotocography, biophysical profile score). 64 neonates: 26 (40%) with cardiac problems, 18 (28%) with abnormal results of prenatal biophysical tests, 14 with IUGR (22%) and 5 (8%) infants whose mothers presented other complications of pregnancy were in the study group. 22 healthy neonates were in the control group. Samples for TnI were taken from umbilical cord during delivery. TnI was determined on dimension clinical chemistry system. The normal range for TnI was 0–0.1 ng/ml. The median cord blood concentration of TnI was 0,01 ± 0.02 ng/ml in healthy controls (range 0–0.05). The incidence of increased concentration of cTnI was significantly higher in infants with abnormal results of prenatal biophysical tests (27.7 vs. 0%, p < 0.05). The corresponding results were very close to significancy in neonates with a history of IUGR (21.4 vs. 0%, p = 0.05). IUGR and fetal distress contrary to cardiac problems (arrhythmia, structural defects) influences umbilical cord TnI concentration. Further investigation is needed to explain whether the course of pregnancy or delivery has essential impact on TnI changes.