P067 Bone manifestations of Haematological Malignancies

Abstract

Abstract Background Bone manifestations complicate many haematological malignancies and usually reflect a progression of the disease, affecting the prognosis (1). Because of the diversity of imaging appearances and clinical behavior of this spectrum of disease, diagnosis can be challenging. The Objectives is to describe the characteristics of bone manifestations in hematologic malignancies. Methods A retrospective descriptive study reviewing the medical records of all patients with hematologic malignancies, hospitalized in an internal medicine department. Results Among 70 patients, 39 men and 31 women were enrolled. The mean age was 55 years (15–83 years). Bone manifestations were related to multiple myeloma (28 cases), Hodgkin's disease (16 cases), non-Hodgkin's lymphoma (13 cases), chronic leukaemia (6 cases), acute leukaemia (5 cases) and Waldenström's disease (2 cases). The clinical presentation was dominated by: an alteration of the general condition (45 cases), peripheral lymphadenopathy (28 cases), hepato-splenomegaly (22 cases), diffuse bone pain (21 cases), back pain (16 cases) and night sweats (13 cases). The complete blood count found cytopenia in 47 cases. Patients presented a biologic inflammatory syndrome (58 cases), kidney failure (23 cases) and hypercalcemia (13 cases). Osteolytic lesions were objectified in 13 cases and vertebral collapse in 4 cases. A myelogram was performed in 40 cases, a lymph node biopsy in 25 cases, a bone marrow biopsy (6 cases) and a bone biopsy in 4 patients. The treatment was based on chemotherapy +/- radiotherapy. Therapeutic abstention was indicated in some patients. Conclusion Multiple myeloma and Hodgkin’s disease have shown the most bone manifestations. Knowledge of the different characteristics of hematological malignancies is essential to enable early diagnosis and appropriate treatment.