P0647 OUTCOMES AND HEALTHCARE UTILIZATION IN A POPULATION-BASED INCEPTION COHORT OF PEDIATRIC CROHN???S DISEASE AND ULCERATIVE COLITIS PATIENTS IN BRITTANY, FRANCE

Abstract

Introduction: Few data are available on outcomes in population-based inception cohorts of pediatric patients with Crohn’s disease (CD) or ulcerative colitis (UC) residing in well-defined geographic areas. Objectives: to evaluate outcomes and healthcare resource utilization within 4 to 7 years of CD or UC diagnosis in children. Methods: All gastroenterologists in Brittany reported new suspected cases of inflammatory bowel disease to the ABER-MAD Registry. In 2001, children with CD (n=45) or UC (n=20) entered between 1994 and 1997 were evaluated for site of involvement (Vienna classification), extraintestinal manifestations, hospital admissions, medical treatments, and surgery. Results: Mean follow-up was 4.3 years and 4 years in the CD (n=45) and UC (n=20) groups, respectively. At last follow-up, 18/45 (40%) patients with CD and 6/20 (30%) with UC had a history of extraintestinal manifestations; 8/45 (17.7%) and 2/20 (10%) CD and UC patients had extension of their bowel lesions. Mean number of drug classes used in the CD group was 2.7: 40/45 (88%) used salicylates, 26/45 (57%) glucocorticoids, 17/45 (37%) azathioprine, 2/45 methotrexate, 1/45 infliximab, 17/45 (37%) enteral nutrition, and 6/45 (13%) parenteral nutrition. All UC patients used salicylates and one-third used glucocorticoids. Surgery was performed in 9/45 (20%) CD patients and none of the UC patients; small bowel and colon resection were required in 6 and 4 CD patients, respectively. Within the CD cohort, 41/45 (91%) had a history of hospital admission with a mean of 2.3 admissions per patient, while 15/20 (75%) of the UC patients had a history of hospital admission with a mean of 1.4 per patient. Conclusion: CD and UC showed little progression within the first 5 years after diagnosis, few patients required inpatient medical care or surgery.