P0629 / #1759: EFFECT OF METABOLIC ACIDOSIS AND NUMBER OF ORGAN DYSFUNCTION ON SURVIVAL IN CHILDREN WITH SEPSIS

Abstract

Aims & Objectives: To evaluate the magnitude of metabolic acidosis and the number of organ dysfunction on survival in children with sepsis in PICU. Methods: An observational prospective study carried out in PICU at Mansoura University Children’s Hospital, Egypt over the period between September 2017 and February 2019. This study included 80 patients of both sexes older than one month, admitted with sepsis and septic shock admitted with metabolic acidosis PH ≤ 7.30. Demographic data were collected. All patients were assessed by PRISM Score III, predicted mortality rate, and evaluated for the number of organ dysfunction in the first 24 hours of admission. Local IRB approved the study protocol. Results: Data were analysed using the software Statistical Package for Social Sciences (SPSS) version 22. The patients were followed for PICU survival and the result was Survivors group (41 patients) and non-survivors group (39 patients). For demographic data, There were no statistically significant differences regarding age, gender (p-value was 0.2, 0.4 respectively), on the other hand, PRISM and predicted death rate showed statistical significance between survivors and non-survivors groups, p-value was 0.03 for both. For the studied variables for both groups, pH on admission showed no statistical significance p-value was 0.1, while the number of organ dysfunction on admission showed a high statistical significance p-value <0.001. Conclusions: The higher number of failing organs on admission was associated with worse outcome; however, the low pH was not.